Spatial and temporal coordination of mitosis by Ran GTPase

被引：329

作者：

Clarke, Paul R. ^{[1
]}

Zhang, Chuanmao ^{[2
,3
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Biomed Res Ctr, Dundee DD1 9SY, Scotland

[2] Peking Univ, Coll Life Sci, Key Lab Cell Proliferat & Differentiat, Minist Educ, Beijing 100871, Peoples R China

[3] Peking Univ, Coll Life Sci, Natl Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrm2410

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.

引用

页码：464 / 477

页数：14

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