Controlled Self-Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging Contrast Agents

被引：137

作者：

Liang, Gaolin ^{[1
,3
]}

Ronald, John ^{[1
]}

Chen, Yuanxin ^{[2
]}

Ye, Deju ^{[1
]}

Pandit, Prachi ^{[1
]}

Ma, Man Lung ^{[1
]}

Rutt, Brian ^{[1
]}

Rao, Jianghong ^{[1
]}

机构：

[1] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Stanford, CA 94305 USA

[2] Univ Western Ontario, Robarts Res Inst, Imaging Res Labs, London, ON N6A 5K8, Canada

[3] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 28期

关键词：

condensation reactions; controlled self-assembly; gadolinium; magnetic nanoparticles; magnetic resonance imaging; BIOCOMPATIBLE CONDENSATION REACTION; MRI CONTRAST; MYELOPEROXIDASE; ENHANCEMENT; GLUTATHIONE; CELLS;

D O I：

10.1002/anie.201007018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gd smart: MRI contrast agents are presented that are based on a biocompatible condensation reaction. Upon reduction, a gadolinium-containing cell-permeable small-molecule probe condenses into cyclic oligomers that subsequently self-assemble into nanoparticles (NPs) with enhanced relaxivity (by 110 % at 1.5 T and 35 °C, and 104 % in live cells at 0.5 T). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6283 / 6286

页数：4

共 30 条

[1]

[Anonymous], ANGEW CHEM, DOI DOI 10.1002/ANGE.200390324

[2] Oligomerization of Paramagnetic Substrates Result in Signal Amplification and can be Used for MR Imaging of Molecular Targets [J].

Bogdanov, Alexei, Jr. ;

Matuszewski, Lars ;

Bremer, Christoph ;

Petrovsky, Alexander ;

Weissleder, Ralph .

MOLECULAR IMAGING, 2002, 1 (01) :16-23

[3] Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].

Caravan, P ;

Ellison, JJ ;

McMurry, TJ ;

Lauffer, RB .

CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352

[4] Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis [J].

Chen, JW ;

Pham, W ;

Weissleder, R ;

Bogdanov, A .

MAGNETIC RESONANCE IN MEDICINE, 2004, 52 (05) :1021-1028

[5] Apoptosis and glutathione: beyond an antioxidant [J].

Franco, R. ;

Cidlowski, J. A. .

CELL DEATH AND DIFFERENTIATION, 2009, 16 (10) :1303-1314

[6] Multifunctional yolk-shell nanoparticles: A potential MRI contrast and anticancer agent [J].

Gao, Jinhao ;

Liang, Gaolin ;

Cheung, Jerry S. ;

Pan, Yue ;

Kuang, Yi ;

Zhao, Fan ;

Zhang, Bei ;

Zhang, Xixiang ;

Wu, Ed X. ;

Xu, Bing .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (35) :11828-11833

[7] THEORY OF 1/T-1 AND 1/T-2 NMRD PROFILES OF SOLUTIONS OF MAGNETIC NANOPARTICLES [J].

KOENIG, SH ;

KELLAR, KE .

MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (02) :227-233

[8]

Lee JH, 2007, NAT MED, V13, P95, DOI [10.1038/nm1467, 10.20659/jfp.13.1_95]

[9] Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential [J].

Li, Lin Z. ;

Zhou, Rong ;

Xu, He N. ;

Moon, Lily ;

Zhong, Tuoxiu ;

Kim, Eun Ju ;

Qiao, Hui ;

Reddy, Ravinder ;

Leeper, Dennis ;

Chance, Britton ;

Glickson, Jerry D. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (16) :6608-6613

[10]

Liang GL, 2010, NAT CHEM, V2, P54, DOI [10.1038/NCHEM.480, 10.1038/nchem.480]

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