Lamotrigine plasma levels reduced by oral contraceptives

被引：151

作者：

Sabers, A ^{[1
]}

Buchholt, JM ^{[1
]}

Uldall, P ^{[1
]}

Hansen, EL ^{[1
]}

机构：

[1] Danish Epilepsy Hosp, DK-4293 Kolonivej 1, Denmark

来源：

EPILEPSY RESEARCH | 2001年 / 47卷 / 1-2期

关键词：

lamotrigine; oral contraceptives; pharmacokinetics; interaction; antiepileptic drugs;

D O I：

10.1016/S0920-1211(01)00305-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although it is known that the use of oral contraceptives (OC's) can induce glucuronide conjugating enzymes, currently no data exists as to the potential that the elimination of the glucuronidated drug lamotrigine (LTG) is increased by OC's. We present seven cases in whom the plasma levels of LTG were significantly decreased by OC's (mean 49% range 41-64%). The interaction was of clinical relevance in most of the patients who either experienced increased seizure frequency/recurrence of seizures after OC's had been added. or adverse effects following withdrawal of OC's. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：151 / 154

页数：4

相关论文

共 14 条

[1] ACUTE EFFECTS OF LAMOTRIGINE (BW430C) IN PERSONS WITH EPILEPSY [J].

BINNIE, CD ;

BOAS, WV ;

KASTELEIJNNOLSTETRENITE, DGA ;

DEKORTE, RA ;

MEIJER, JWA ;

MEINARDI, H ;

MILLER, AA ;

OVERWEG, J ;

PECK, AW ;

VANWIERINGEN, A ;

YUEN, WC .

EPILEPSIA, 1986, 27 (03) :248-254

[2] A LIQUID-CHROMATOGRAPHIC ASSAY USING A HIGH-SPEED COLUMN FOR THE DETERMINATION OF LAMOTRIGINE, A NEW ANTIEPILEPTIC DRUG, IN HUMAN PLASMA [J].

FAZIO, A ;

ARTESI, C ;

RUSSO, M ;

TRIO, R ;

OTERI, G ;

PISANI, F .

THERAPEUTIC DRUG MONITORING, 1992, 14 (06) :509-512

[3] LAMOTRIGINE - AN UPDATE OF ITS PHARMACOLOGY AND THERAPEUTIC USE IN EPILEPSY [J].

FITTON, A ;

GOA, KL .

DRUGS, 1995, 50 (04) :691-713

[4] Lamotrigine: Pharmacokinetics [J].

Garnett, WR .

JOURNAL OF CHILD NEUROLOGY, 1997, 12 :S10-S15

[5]

HOLDICH T, 1991, Epilepsia, V32, P96

[6] LAMOTRIGINE - SINGLE-DOSE PHARMACOKINETICS AND INITIAL 1 WEEK EXPERIENCE IN REFRACTORY EPILEPSY [J].

JAWAD, S ;

YUEN, WC ;

PECK, AW ;

HAMILTON, MJ ;

OXLEY, JR ;

RICHENS, A .

EPILEPSY RESEARCH, 1987, 1 (03) :194-201

[7] Lamotrigine high-dose tolerability and safety in patients with epilepsy: A double-blind, placebo-controlled, eleven-week study [J].

Matsuo, F ;

Gay, P ;

Madsen, J ;

Tolman, KG ;

Rollins, DE ;

Risner, ME ;

Lai, AA .

EPILEPSIA, 1996, 37 (09) :857-862

[8] Influence of oxcarbazepine and methsuximide on lamotrigine concentrations in epileptic patients with and without valproic acid comedication:: Results of a retrospective study [J].

May, TW ;

Rambeck, B ;

Jürgens, U .

THERAPEUTIC DRUG MONITORING, 1999, 21 (02) :175-181

[9] DRUG GLUCURONIDATION IN HUMANS [J].

MINERS, JO ;

MACKENZIE, PI .

PHARMACOLOGY & THERAPEUTICS, 1991, 51 (03) :347-369

[10] Lamotrigine in pregnancy: Pharmacokinetics during delivery, in the neonate, and during lactation [J].

Ohman, I ;

Vitols, S ;

Tomson, T .

EPILEPSIA, 2000, 41 (06) :709-713