5-HT4 receptors, a place in the sun: act two

被引：62

作者：

Bockaert, Joel ^{[1
,2
]}

Claeysen, Sylvie ^{[1
,2
]}

Compan, Valerie ^{[1
,2
]}

Dumuis, Aline ^{[1
,2
]}

机构：

[1] Univ Montpellier, CNRS, Inst Genom Fonct, UMR5203, F-34094 Montpellier, France

[2] INSERM, U661, F-34094 Montpellier, France

来源：

CURRENT OPINION IN PHARMACOLOGY | 2011年 / 11卷 / 01期

关键词：

LONG-TERM POTENTIATION; G-PROTEIN; PYRAMIDAL NEURONS; FOOD-INTAKE; BRAIN; RAT; ACTIVATION; HIPPOCAMPUS; AGONISTS; DEPRESSION;

D O I：

10.1016/j.coph.2011.01.012

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

5-HT4 receptors control brain physiological functions such as learning and memory, feeding and mood behaviour as well as gastro-intestinal transit. 5-HT4 receptors are one of the 5-HT receptors for which the available drugs and signalling knowledge are the most advanced. Several therapeutic 5-HT4 receptor drugs have been commercialized. Therefore, the hope that 5-HT4 receptors could also be the target for brain diseases is reasonable. Several major devastating illnesses could benefit from 5-HT4 receptors-directed therapy such as Alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders.

引用

收藏

页码：87 / 93

页数：7

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