Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α-Trifluoromethyl Carbonyl Compounds

被引：405

作者：

Pham, Phong V. ^{[1
]}

Nagib, David A. ^{[1
]}

MacMillan, David W. C. ^{[1
]}

机构：

[1] Princeton Univ, Merck Ctr Catalysis, Princeton, NJ 08544 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 27期

关键词：

enolsilanes; photoredox catalysis; alpha-perfluoroalkylation; alpha-trifluoromethylation; SILYL ENOL ETHERS; VISIBLE-LIGHT PHOTOCATALYSIS; PHOTOINDUCED-ELECTRON-TRANSFER; C-H FUNCTIONALIZATION; ELECTROCHEMICAL OXIDATION; MEDICINAL CHEMISTRY; CATION-RADICALS; KETENE ACETALS; ALDEHYDES; ORGANOCATALYSIS;

D O I：

10.1002/anie.201101861

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6119 / 6122

页数：4

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