Two proazulenes from Achillea ceretanica Sennen

被引：6

作者：

Glasl, S

Presser, A

Werner, I

Wawrosch, C

Kastner, U

Jurenitsch, J

Haslinger, E

Kubelka, W

机构：

[1] Univ Vienna, Pharm Zentrum, Inst Pharmakognosie, A-1090 Vienna, Austria

[2] Graz Univ, Inst Pharmazeut Chem, A-8010 Graz, Austria

来源：

PHYTOCHEMISTRY | 1999年 / 50卷 / 04期

关键词：

Achillea ceretanica; Compositae; guaianolides; sesquiterpene lactones; proazulenes;

D O I：

10.1016/S0031-9422(98)00595-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From flower heads of a tetraploid clone of Achillea ceretanica two further guaianolides were isolated by repeated column chromatography and HPLC. The constitution and the stereochemistry of these new, unstable compounds were determined by MS, one- and two-dimensional NMR-techniques (H-1-,C-13-NMR, COSY-, HSQC-, TOCSY-, selective TOCSY- and NOE-experiments) as well as by comparison to the data of the literature. The two substances were identified as 2 alpha,8 alpha-dihydroxy-1 alpha,5 alpha,6 beta,7 alpha,11 beta H-guaia-3,10(14)-dien-12,6-olide and its 8 alpha-acetate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：629 / 631

页数：3

共 5 条

[1]

Glasl S., 1997, Pharmaceutical and Pharmacological Letters, V7, P119

[2]

SERKEROV SV, 1984, KHIM PRIR SOEDIN, V5, P595

[3]

STAHL E, 1967, DUNNSCHICHT CHROMATO, P825

[4] EXCITATION SCULPTING IN HIGH-RESOLUTION NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY - APPLICATION TO SELECTIVE NOE EXPERIMENTS [J].

STOTT, K ;

STONEHOUSE, J ;

KEELER, J ;

HWANG, TL ;

SHAKA, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (14) :4199-4200

[5]

Wawrosch C., 1997, Pharmaceutical and Pharmacological Letters, V7, P116

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