Successful Transmission of a Retrovirus Depends on the Commensal Microbiota

被引：289

作者：

Kane, Melissa ^{[1
]}

Case, Laure K. ^{[1
]}

Kopaskie, Karyl ^{[1
]}

Kozlova, Alena ^{[1
]}

MacDearmid, Cameron ^{[1
]}

Chervonsky, Alexander V. ^{[2
]}

Golovkina, Tatyana V. ^{[1
]}

机构：

[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

SCIENCE | 2011年 / 334卷 / 6053期

关键词：

MAMMARY-TUMOR VIRUS; TOLL-LIKE RECEPTORS; INNATE IMMUNITY; ORAL TOLERANCE; T-CELLS; RECOGNITION; MICROFLORA; INFECTION; FLORA; HIV;

D O I：

10.1126/science.1210718

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To establish chronic infections, viruses must develop strategies to evade the host's immune responses. Many retroviruses, including mouse mammary tumor virus (MMTV), are transmitted most efficiently through mucosal surfaces rich in microbiota. We found that MMTV, when ingested by newborn mice, stimulates a state of unresponsiveness toward viral antigens. This process required the intestinal microbiota, as antibiotic-treated mice or germ-free mice did not transmit infectious virus to their offspring. MMTV-bound bacterial lipopolysaccharide triggered Toll-like receptor 4 and subsequent interleukin-6 (IL-6)-dependent induction of the inhibitory cytokine IL-10. Thus, MMTV has evolved to rely on the interaction with the microbiota to induce an immune evasion pathway. Together, these findings reveal the fundamental importance of commensal microbiota in viral infections.

引用

页码：245 / 249

页数：5

共 28 条

[1] Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii [J].