Nanofibrous poly(lactic acid)/hydroxyapatite composite scaffolds for guided tissue regeneration

被引：105

作者：

Jeong, Sung In ^{[2
]}

Ko, Eun Kyoung ^{[1
]}

Yum, Jungsuk ^{[1
]}

Jung, Chul Ho ^{[2
]}

Lee, Young Moo ^{[2
]}

Shin, Heungsoo ^{[1
]}

机构：

[1] Hanyang Univ, Dept Bioengn, Coll Engn, Seongdong Ku, Seoul 133791, South Korea

[2] Hanyang Univ, Sch Chem Engn, Coll Engn, Seongdong Ku, Seoul 133791, South Korea

来源：

MACROMOLECULAR BIOSCIENCE | 2008年 / 8卷 / 04期

关键词：

D O I：

10.1002/mabi.200700107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The production of nanofibrous PLA/HA composite scaffolds is described. The morphological, mechanical, surface, and thermal properties of the composites were extensively investigated. The results show that the mixture of PLA and HA formed smooth nanofibers without lumps. The incorporation of HA increased the mechanical strength of the nanofibers and changed the morphology, increasing the mean fiber diameter and pore size. Surface and internal properties confirmed that HA was homogeneously distributed inside the nanofibers and oriented towards their surface. The nanofiber composites allowed the adhesion and proliferation of pre-osteoblasts for up to 3 weeks.

引用

页码：328 / 338

页数：11

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