Hot-Topic Debate on Hepatitis C Virus: The Type of Immunosuppression Matters

被引：10

作者：

Trotter, James F. ^{[1
]}

机构：

[1] Baylor Univ Med Ctr, Dallas, TX 75246 USA

来源：

LIVER TRANSPLANTATION | 2011年 / 17卷

关键词：

LIVER-TRANSPLANT RECIPIENTS; SUSTAINED VIROLOGICAL RESPONSE; ANTIVIRAL THERAPY; MYCOPHENOLATE-MOFETIL; FIBROSIS PROGRESSION; CYCLOSPORINE-A; IN-VITRO; RECURRENCE; PREDICTORS; INFECTION;

D O I：

10.1002/lt.22414

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Key Points 1. The treatment of rejection is an important factor associated with the severe recurrence of hepatitis C virus (HCV) after liver transplantation. 2. The effects of calcineurin inhibitors, corticosteroids, and mycophenolate mofetil on HCV recurrence are equivocal. 3. Cyclosporine is associated with a higher sustained virological response in patients treated for HCV. 4. Because insulin resistance and diabetes are associated with fibrosis in HCV-infected liver transplant recipients, the use of immunosuppressive agents without this side effect may slow the posttransplant disease progression. Liver Transpl 17:S20-S23, 2011. (C) 2011 AASLD.

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收藏

页码：S20 / S23

页数：4

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