Structure-Based Design for High-Hanging Vaccine Fruits

被引：6

作者：

Back, Jaap W. ^{[2
]}

Langedijk, Johannes P. M. ^{[1
]}

机构：

[1] Crucell Innovat & Discovery Lab, Leiden, Netherlands

[2] Pepscan Therapeut, Lelystad, Netherlands

来源：

ADVANCES IN IMMUNOLOGY , VOL 114: SYNTHETIC VACCINES | 2012年 / 114卷

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODIES; NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEIN; HIV-1; GP120; BROAD NEUTRALIZATION; CRYSTAL-STRUCTURES; MOUTH-DISEASE; BINDING MODE; GP41; EPITOPE;

D O I：

10.1016/B978-0-12-396548-6.00002-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although vaccines have proven life saving against a myriad of infectious diseases, various pathogens have remained refractory to prophylaxis of their host by active immunization. New insights in the three dimensional (3D) structure, domain organization and dynamics of viral and bacterial surface proteins can guide the design of effective vaccines in several ways. In this review we highlight recent developments in structure-based vaccine design that are aimed at stabilization of native conformations and focusing immune response to conserved epitopes. Detailed 3D structures of pathogen surface proteins provide knowledge on how to minimize complex antigens or how to redesign the surface of an immunogen in order to induce only relevant neutralizing antibodies against a broad range of serotypes. Structure - based vaccines with reduced complexity and broad efficacy could greatly enhance the number of people that might benefit from the therapies that are developed.

引用

收藏

页码：33 / 50

页数：18

相关论文

共 82 条

[1] Broad Neutralization of Human Immunodeficiency Virus Type 1 (HIV-1) Elicited from Human Rhinoviruses That Display the HIV-1 gp41 ELDKWA Epitope [J].

Arnold, Gail Ferstandig ;

Velasco, Paola K. ;

Holmes, Andrew K. ;

Wrin, Terri ;

Geisler, Sheila C. ;

Phung, Pham ;

Tian, Yu ;

Resnick, Dawn A. ;

Ma, Xuejun ;

Mariano, Thomas M. ;

Petropoulos, Christos J. ;

Taylor, John W. ;

Katinger, Hermann ;

Arnold, Eddy .

JOURNAL OF VIROLOGY, 2009, 83 (10) :5087-5100

[2] Challenges in the development of an HIV-1 vaccine [J].

Barouch, Dan H. .

NATURE, 2008, 455 (7213) :613-619

[3] Structure of antibody f425-b4e8 in complex with a v3 peptide reveals a new binding mode for HIV-1 neutralization [J].

Bell, Christian H. ;

Pantophlet, Ralph ;

Schiefner, Andre ;

Cavacini, Lisa A. ;

Stanfield, Robyn L. ;

Burton, Dennis R. ;

Wilson, Ian A. .

JOURNAL OF MOLECULAR BIOLOGY, 2008, 375 (04) :969-978

[4] Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates [J].

Bianchi, Elisabetta ;

Joyce, Joseph G. ;

Miller, Michael D. ;

Finnefrock, Adam C. ;

Liang, Xiaoping ;

Finotto, Marco ;

Ingallinella, Paolo ;

McKenna, Philip ;

Citron, Michael ;

Ottinger, Elizabeth ;

Hepler, Robert W. ;

Hrin, Renee ;

Nahas, Deborah ;

Wu, Chengwei ;

Montefiori, David ;

Shiver, John W. ;

Pessi, Antonello ;

Kim, Peter S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (23) :10655-10660

[5] Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies [J].

Binley, JA ;

Wrin, T ;

Korber, B ;

Zwick, MB ;

Wang, M ;

Chappey, C ;

Stiegler, G ;

Kunert, R ;

Zolla-Pazner, S ;

Katinger, H ;

Petropoulos, CJ ;

Burton, DR .

JOURNAL OF VIROLOGY, 2004, 78 (23) :13232-13252

[6] A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure [J].

Binley, JM ;

Sanders, RW ;

Clas, B ;

Schuelke, N ;

Master, A ;

Guo, Y ;

Kajumo, F ;

Anselma, DJ ;

Maddon, PJ ;

Olson, WC ;

Moore, JP .

JOURNAL OF VIROLOGY, 2000, 74 (02) :627-643

[7] Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge [J].

Bommakanti, Gayathri ;

Citron, Michael P. ;

Hepler, Robert W. ;

Callahan, Cheryl ;

Heidecker, Gwendolyn J. ;

Najar, Tariq Ahmad ;

Lu, Xianghan ;

Joyce, Joseph G. ;

Shiver, John W. ;

Casimiro, Danilo R. ;

ter Meulen, Jan ;

Liang, Xiaoping ;

Varadarajan, Raghavan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (31) :13701-13706

[8] Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody [J].

Brunel, FM ;

Zwick, MB ;

Cardoso, RMF ;

Nelson, JD ;

Wilson, IA ;

Burton, DR ;

Dawson, PE .

JOURNAL OF VIROLOGY, 2006, 80 (04) :1680-1687

[9] Structural Basis of the Cross-Reactivity of Genetically Related Human Anti-HIV-1 mAbs: Implications for Design of V3-Based Immunogens [J].

Burke, Valicia ;

Williams, Constance ;

Sukumaran, Madhav ;

Kim, Seung-Sup ;

Li, Huiguang ;

Wang, Xiao-Hong ;

Gorny, Miroslaw K. ;

Zolla-Pazner, Susan ;

Kong, Xiang-Peng .

STRUCTURE, 2009, 17 (11) :1538-1546

[10] Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10 [J].

Cardoso, Rosa M. F. ;

Brunel, Florence M. ;

Ferguson, Sharon ;

Zwick, Michael ;

Burton, Dennis R. ;

Dawson, Philip E. ;

Wilson, Ian A. .

JOURNAL OF MOLECULAR BIOLOGY, 2007, 365 (05) :1533-1544

← 1 2 3 4 5 6 7 8 9 →