Do matrix metalloproteinases MMP-2 and MMP-9 (gelatinases) play a role in renal development, physiology and glomerular diseases?

被引：73

作者：

Lelongt, B

Legallicier, B

Piedagnel, R

Ronco, PN

机构：

[1] Hop Tenon, Div Renal, F-75020 Paris, France

[2] Hop Tenon, INSERM, U489, Assistance Publ Hop Paris, F-75020 Paris, France

[3] Univ Paris 06, Hop Tenon, Assistance Publ Hop Paris, Paris, France

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 01期

关键词：

D O I：

10.1097/00041552-200101000-00002

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Metalloproteinases MMP-2 and MMP-9 (also called gelatinases) are involved in cell invasion and in embryonic development and organogenesis. A growing number of reports suggest that MMP-2 and MMP-9 play some role in renal development, renal tubule physiology and glomerular pathophysiology. This editorial will focus on recent controversial data, especially those obtained from studies on MMP-9- deficient mice, which shed new light on the functions of gelatinases in normal and diseased kidneys. Curr Opin Nephrol Hypertens 10:7-12. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：7 / 12

页数：6

共 43 条

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Alexander CM, 1996, DEVELOPMENT, V122, P1723

[2] Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome [J].