Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies

被引：67

作者：

Katsuse, O ^{[1
]}

Iseki, E ^{[1
]}

Marui, W ^{[1
]}

Kosaka, K ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Psychiat, Kanazawa, Ishikawa 2360004, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2003年 / 211卷 / 1-2期

关键词：

Lewy body; dementia with Lewy bodies; alpha-synuclein; axonal transport blockage; axonal transport substances;

D O I：

10.1016/S0022-510X(03)00037-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated 10 dementia with Lewy bodies (DLB) brains showing various degrees of Lewy pathology using alpha-synuclein-immunohistochemistry, and morphologically divided cortical Lewy bodies (LB) into six developmental stages. Further, we demonstrated the ultrastructure of each stage of cortical LB using alpha-synuclein-immunoelectron microscopy. In the initial stage, alpha-synuclein accumulated in part of the neuronal cytoplasm without filamentous components, then formed LB and LB-related neurites composed of granulo-filamentous components. Finally, LB degraded to extracellular LB composed of loose filamentous components with involved astroglial processes. In addition, we immunohistochemically investigated the accumulation of axonal transported substances in cortical LB, and showed that APP, chromogranin-A. synphilin-1 and synaptophysin accumulated in cortical LB from stages 1, 2, 3 and 4, respectively. These findings suggest that chronic axonal transport blockage is implicated in the development of cortical LB in DLB brains. (C) 2003 Elsevier Science B.V All rights reserved.

引用

页码：29 / 35

页数：7

共 35 条

[31]

Wakabayashi K, 2000, ANN NEUROL, V47, P521, DOI 10.1002/1531-8249(200004)47:4<521::AID-ANA18>3.3.CO

[32]

2-2

[33] Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy [J].

Wakabayashi, K ;

Hayashi, S ;

Kakita, A ;

Yamada, M ;

Toyoshima, Y ;

Yoshimoto, M ;

Takahashi, H .

ACTA NEUROPATHOLOGICA, 1998, 96 (05) :445-452

[34] IMMUNOCYTOCHEMICAL LOCALIZATION OF SYNAPTIC VESICLE-SPECIFIC PROTEIN IN LEWY BODY-CONTAINING NEURONS IN PARKINSONS-DISEASE [J].

WAKABAYASHI, K ;

TAKAHASHI, H ;

OBATA, K ;

IKUTA, F .

NEUROSCIENCE LETTERS, 1992, 138 (02) :237-240

[35] EXPRESSION OF CHROMOGRANIN-A IN LESIONS IN THE CENTRAL-NERVOUS-SYSTEM FROM PATIENTS WITH NEUROLOGICAL DISEASES [J].

YASUHARA, O ;

KAWAMATA, T ;

AIMI, Y ;

MCGEER, EG ;

MCGEER, PL .

NEUROSCIENCE LETTERS, 1994, 170 (01) :13-16

← 1 2 3 4 →