Inactive yet indispensable: the tale of Jarid2

被引：70

作者：

Landeira, David ^{[1
]}

Fisher, Amanda G. ^{[1
]}

机构：

[1] Imperial Coll Sch Med, Lymphocyte Dev Grp, MRC Clin Sci Ctr, London W12 0NN, England

来源：

TRENDS IN CELL BIOLOGY | 2011年 / 21卷 / 02期

基金：

英国医学研究理事会;

关键词：

RNA-POLYMERASE-II; JUMONJI GENE; STEM-CELLS; DEVELOPMENTAL REGULATORS; CARDIAC DEVELOPMENT; NUCLEAR-PROTEIN; POLYCOMB; TRANSCRIPTION; CHROMATIN; FAMILY;

D O I：

10.1016/j.tcb.2010.10.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methylation of histone tails is believed to be important for the establishment and inheritance of gene expression programs during development. Jarid2/Jumonji is the founding member of a family of chromatin modifiers with histone demethylase activity. Although Jarid2 contains amino acid substitutions that are thought to abolish its catalytic activity, it is essential for the development of multiple organs in mice. Recent studies have shown that Jarid2 is a component of the polycomb repressive complex 2 and is required for embryonic stem (ES) cell differentiation. Here, we discuss current literature on the function of Jarid2 and hypothesize that defects resulting from Jarid2 deficiency arise from a failure to correctly prime genes in ES cells that are required for later stages in development.

引用

页码：74 / 80

页数：7

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