Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors

被引：47

作者：

Chen, Zhiqiang

Kujawa, Sharon G.

Sewell, William F.

机构：

[1] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02114 USA

[2] Massachusetts Eye & Ear Infirm, Eaton Peabody Lab, Dept Otolaryngol, Boston, MA 02114 USA

[3] Massachusetts Eye & Ear Infirm, Dept Audiol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 10期

关键词：

D O I：

10.1038/nn1974

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report a robust regulation of surface AMPA receptors in mouse auditory neurons, both with application of glutamate receptor agonists in cultured neurons and in response to acoustic stimulation in vivo. The reversible reduction of surface AMPA receptors following acoustic stimulation correlated with changes in acoustic sensitivity. Thus we show that AMPA receptor cycling is important for optimizing synaptic transfer at one of the most exacting synapses in the body.

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页码：1238 / 1240

页数：3

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