Commitment to X inactivation precedes the twinning event in monochorionic MZ twins

被引：94

作者：

Monteiro, J

Derom, C

Vlietinck, R

Kohn, N

Lesser, M

Gregersen, PK

机构：

[1] NYU, Sch Med, N Shore Univ Hosp, Dept Med,Div Biol & Human Genet, Manhasset, NY 11030 USA

[2] NYU, Sch Med, N Shore Univ Hosp, Dept Res,Div Biostat, Manhasset, NY 11030 USA

[3] Katholieke Univ Leuven, Ctr Human Genet, B-3001 Leuven, Belgium

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 1998年 / 63卷 / 02期

关键词：

D O I：

10.1086/301978

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To gain insight into the timing of twinning, we have examined a closely related event, X-chromosome inactivation, in female MZ twin pairs. X-inactivation patterns in peripheral blood and buccal mucosa were compared between monochorionic MZ (MC-MZ) and dichorionic MZ (DC-MZ) twins. Overall, the MC-MZ twins displayed highly similar X-inactivation patterns, whereas DC-MZ twins frequently differed in their X-inactivation patterns, when both tissues were tested. Previous experimental data suggest that commitment to X inactivation occurs when there are 10-20 cells in the embryo. Simulation of embryo splitting after commitment to X inactivation suggests that MC-MZ twinning occurs three or four rounds of replication after X inactivation, whereas a DC-MZ twinning event occurs earlier, before or around the time of X inactivation. Finally, the overall degree of skewing in the MZ twins was not significantly different from that observed in singletons. This indicates that X inactivation does not play a direct role in the twinning process, and it further suggests that extreme unequal splitting is not a common mechanism of twin formation.

引用

页码：339 / 346

页数：8

共 21 条

[1]

ALLEN RC, 1992, AM J HUM GENET, V51, P1229

[2]

Bamforth F, 1996, AM J MED GENET, V61, P209

[3]

Busque L, 1996, BLOOD, V88, P59

[4]

Derom R, 1995, MULTIPLE PREGNANCY E, P113

[5]

Goodship J, 1996, AM J MED GENET, V61, P205, DOI 10.1002/(SICI)1096-8628(19960122)61:3<205::AID-AJMG3>3.0.CO

[6]

2-T

[7]

HOGAN B, 1994, MANIPULATING MOUSE E, P20

[8]

Jarvik GP, 1997, AM J HUM GENET, V61, pA102

[9] DISCORDANCE OF MUSCULAR-DYSTROPHY IN MONOZYGOTIC FEMALE TWINS - EVIDENCE SUPPORTING ASYMMETRIC SPLITTING OF THE INNER CELL MASS IN A MANIFESTING CARRIER OF DUCHENNE DYSTROPHY [J].

LUPSKI, JR ;

GARCIA, CA ;

ZOGHBI, HY ;

HOFFMAN, EP ;

FENWICK, RG .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1991, 40 (03) :354-364

[10] OLIGOCLONALITY IN THE HUMAN CD8(+) T-CELL REPERTOIRE IN NORMAL SUBJECTS AND MONOZYGOTIC TWINS - IMPLICATIONS FOR STUDIES OF INFECTIOUS AND AUTOIMMUNE-DISEASES [J].

MONTEIRO, J ;

HINGORANI, R ;

CHOI, IH ;

SILVER, J ;

PERGOLIZZI, R ;

GREGERSEN, PK .

MOLECULAR MEDICINE, 1995, 1 (06) :614-624

← 1 2 3 →