Tanshinone: An inhibitor of proliferation of vascular smooth muscle cells

被引：89

作者：

Wang, H ^{[1
]}

Gao, XM ^{[1
]}

Zhang, BL ^{[1
]}

机构：

[1] Tianjin Coll Tradit Chinese Med, Res Ctr Tradit Chinese Med, Tianjin 300193, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 99卷 / 01期

基金：

中国国家自然科学基金;

关键词：

tanshinone (Tan); vascular smooth muscle cells (VSMCs); cell proliferation; extracellular signal-regulated kinase1/2 (ERK1/2); cell cycle;

D O I：

10.1016/j.jep.2005.01.057

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Tanshinone (Tan) is one of the active components of Radix Salvia miltiorrhiza (Lamiaceae), which is clinically used to treat cardiovascular diseases in China. The aim of this study was to estimate the effect of Tan on the proliferation of cultured vascular smooth muscle cells (VSMCs) induced by fatal bovine serum (FBS). It was shown that various concentrations of Tan inhibited the VSMCs proliferation in a dose-dependent manner. Tan significantly blocked VSMCs cell cycle in G(0)/G(1) phase. The anti-proliferative effect of Tan was associated with the inhibition of the extracellular signal-regulated kinase1/2 (ERK1/2). On the other hand, the decrement of Tan on the cyclin D1 protein may be related to the high expression of p21(waf/cip1). The data suggest that the anti-proliferative effect of Tan on VSMCs proliferation was associated with ERK1/2 signaling pathway. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：93 / 98

页数：6

共 29 条

[1]

Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases [J].

Bennett, AM ;

Tonks, NK .

SCIENCE, 1997, 278 (5341) :1288-1291

[2]

ERKS - A FAMILY OF PROTEIN-SERINE THREONINE KINASES THAT ARE ACTIVATED AND TYROSINE PHOSPHORYLATED IN RESPONSE TO INSULIN AND NGF [J].

BOULTON, TG ;

NYE, SH ;

ROBBINS, DJ ;

IP, NY ;

RADZIEJEWSKA, E ;

MORGENBESSER, SD ;

DEPINHO, RA ;

PANAYOTATOS, N ;

COBB, MH ;

YANCOPOULOS, GD .

CELL, 1991, 65 (04) :663-675

[3]

Identification of MAP kinase domains by redirecting stress signals into growth factor responses [J].

Brunet, A ;

Pouyssegur, J .

SCIENCE, 1996, 272 (5268) :1652-1655

[4]

ADENOVIRUS-MEDIATED OVER-EXPRESSION OF THE CYCLIN CYCLIN-DEPENDENT KINASE INHIBITOR, P21 INHIBITS VASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION AND NEOINTIMA FORMATION IN THE RAT CAROTID-ARTERY MODEL OF BALLOON ANGIOPLASTY [J].

CHANG, MW ;

BARR, E ;

LU, MM ;

BARTON, K ;

LEIDEN, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2260-2268

[5]

Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts [J].

Edelmann, HML ;

Kuhne, C ;

Petritsch, C ;

Ballou, LM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) :963-971

[6]

Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase [J].

Eguchi, S ;

Inagami, T .

REGULATORY PEPTIDES, 2000, 91 (1-3) :13-20

[7]

Growth factors and mitogen activated protein kinases [J].

Force, T ;

Bonventre, JV .

HYPERTENSION, 1998, 31 (01) :152-161

[8]

Regulation of G1 phase progression by growth factors and the extracellular matrix [J].

Hulleman, E ;

Boonstra, J .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (01) :80-93

[9]

CYCLINS AND CANCER .2. CYCLIN-D AND CDK INHIBITORS COME OF AGE [J].

HUNTER, T ;

PINES, J .

CELL, 1994, 79 (04) :573-582

[10]

ISOLATION AND BIOACTIVITY OF NEW TANSHINONES [J].

LEE, AR ;

WU, WL ;

CHANG, WL ;

LIN, HC ;

KING, ML .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (02) :157-160

← 1 2 3 →