Vitamin C mediated protection on cisplatin induced mutagenicity in mice

被引:67
作者
Giri, A [1 ]
Khynriam, D [1 ]
Prasad, SB [1 ]
机构
[1] NE Hill Univ, Sch Life Sci, Dept Zool, Cell & Tumour Biol Lab, Shillong 793022, Meghalaya, India
关键词
cisplatin; vitamin C; mutagenicity; chromosomal aberration; micronucleus; sperm-shape abnormality;
D O I
10.1016/S0027-5107(98)00158-4
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In present studies the development of chromosomal aberrations, micronuclei in bone marrow cells and sperm head abnormalities were used as mutagenic bioassay in Swiss albino mice treated with cisplatin alone or ascorbic plus cisplatin. It was noted that in the combined treated hosts the frequency of all the mutagenic parameters were always significantly less than that treated with cisplatin alone. These findings suggest a protective role of ascorbic acid against cisplatin induced mutagenic potentials. Interestingly, in combined treated hosts glutathione (GSH) level in bone marrow cells increased significantly which may suggest a possible mechanism of ascorbic acid mediated protection against cisplatin induced mutagenic potentials in the hosts. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:139 / 148
页数:10
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