The GUDMAP database - an online resource for genitourinary research

被引：185

作者：

Harding, Simon D. ^{[1
]}

Armit, Chris ^{[2
]}

Armstrong, Jane ^{[2
]}

Brennan, Jane ^{[2
]}

Cheng, Ying ^{[1
]}

Haggarty, Bernard ^{[1
]}

Houghton, Derek ^{[1
]}

Lloyd-MacGilp, Sue ^{[2
]}

Pi, Xingjun ^{[1
]}

Roochun, Yogmatee ^{[1
]}

Sharghi, Mehran ^{[1
]}

Tindal, Christopher ^{[1
]}

McMahon, Andrew P. ^{[3
,4
]}

Gottesman, Brian ^{[3
,4
]}

Little, Melissa H. ^{[5
]}

Georgas, Kylie ^{[5
]}

Aronow, Bruce J. ^{[6
]}

Potter, S. Steven ^{[7
]}

Brunskill, Eric W. ^{[7
]}

Southard-Smith, E. Michelle ^{[8
]}

Mendelsohn, Cathy ^{[9
]}

Baldock, Richard A. ^{[1
]}

Davies, Jamie A. ^{[2
]}

Davidson, Duncan ^{[1
]}

机构：

[1] Western Gen Hosp, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland

[3] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[4] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[5] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4067, Australia

[6] Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA

[7] Cincinnati Childrens Hosp Med Ctr, Div Dev Biol, Cincinnati, OH 45229 USA

[8] Vanderbilt Univ, Dept Med, Sch Med, Div Genet Med, Nashville, TN 37232 USA

[9] Columbia Univ, Dept Urol & Pathol, New York, NY 10032 USA

来源：

DEVELOPMENT | 2011年 / 138卷 / 13期

基金：

美国国家卫生研究院;

关键词：

Database; Gene expression; Genitourinary; In situ hybridisation; Microarray; GENE-EXPRESSION ANALYSIS; DEVELOPING KIDNEY; NEPHRON; PATTERNS; REVEALS; ARCHIVE; EMBRYO; ATLAS; EMAGE;

D O I：

10.1242/dev.063594

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is an international consortium working to generate gene expression data and transgenic mice. GUDMAP includes data from large-scale in situ hybridisation screens (wholemount and section) and microarray gene expression data of microdissected, laser-captured and FACS-sorted components of the developing mouse genitourinary (GU) system. These expression data are annotated using a high-resolution anatomy ontology specific to the developing murine GU system. GUDMAP data are freely accessible at www.gudmap.org via easy-to-use interfaces. This curated, high-resolution dataset serves as a powerful resource for biologists, clinicians and bioinformaticians interested in the developing urogenital system. This paper gives examples of how the data have been used to address problems in developmental biology and provides a primer for those wishing to use the database in their own research.

引用

页码：2845 / 2853

页数：9

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