Biomolecule-assisted synthesis of water-soluble silver nanoparticles and their biomedical applications

被引：103

作者：

Wu, Qingzhi ^{[1
]}

Cao, Huaqiang ^{[1
,3
]}

Luan, Qiuying ^{[2
]}

Zhang, Jiyong ^{[2
]}

Wang, Zhao ^{[2
]}

Warner, Jamie H. ^{[3
]}

Watt, Andrew A. R. ^{[3
]}

机构：

[1] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China

[3] Univ Oxford, Dept Mat, Oxford OX1 3PH, England

来源：

INORGANIC CHEMISTRY | 2008年 / 47卷 / 13期

关键词：

D O I：

10.1021/ic8002228

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The application of nanoparticles in the biomedical field is an exciting interdisciplinary research area in current materials science. In the present study, size-tunable and water-soluble noble metal silver nanoparticles (Ag NPs) have been successfully synthesized with the assistance of glutathione (GSH). The as-synthesized Ag NPs are ready to bind covalently with a model protein (bovine serum albumin) in mild conditions. The optical property of surface-modifiable Ag NPs was extremely sensitive to their size and the surface modification, suggesting a potential in the biomedical analysis and detection. Furthermore, Ag NPs with an average diameter of ca. 6 nm effectively suppress the proliferation of human leukemic K562 cells in the dose- and time-dependent manners, suggesting the promising potential of Ag NPs in cancer therapy.

引用

页码：5882 / 5888

页数：7

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