Recognition of classical and heavy chain forms of HLA-B27 by leukocyte receptors

被引:35
作者
Allen, RL [1 ]
Trowsdale, J [1 ]
机构
[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
基金
英国医学研究理事会;
关键词
D O I
10.2174/1566524043479329
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
As an MHC class I protein, the disease association of HLA-B27 with inflammatory arthritis has been widely assumed to imply a role for the T cell antigen receptor (TCR) in disease. However, in addition to their classical antigen-presenting role, HLA class I proteins are recognised by members of the killer immunoglobulin receptor (KIR) and leukocyte immunoglobulin-like receptor (LILR/ILT/LIR) families. Unusual properties of HLA-B27 include an ability of free heavy chains (FHC) to reach the cell surface in the absence Of beta(2)m and to maintain their peptide-binding groove in vitro. This review describes immunomodulatory receptors that recognise HLA class 1, and the recognition of HLA-B27 in both the classical beta(2)m-associated and beta(2)m-independent forms by members of the KIR and LILR families. Alternative recognition of different forms of HLA-B27 by leukocyte receptors could influence the function of cells from both innate and adaptive immune systems, and may indicate a role for various leukocyte populations in HLA-B27-associated inflammatory disease.
引用
收藏
页码:59 / 65
页数:7
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