As an MHC class I protein, the disease association of HLA-B27 with inflammatory arthritis has been widely assumed to imply a role for the T cell antigen receptor (TCR) in disease. However, in addition to their classical antigen-presenting role, HLA class I proteins are recognised by members of the killer immunoglobulin receptor (KIR) and leukocyte immunoglobulin-like receptor (LILR/ILT/LIR) families. Unusual properties of HLA-B27 include an ability of free heavy chains (FHC) to reach the cell surface in the absence Of beta(2)m and to maintain their peptide-binding groove in vitro. This review describes immunomodulatory receptors that recognise HLA class 1, and the recognition of HLA-B27 in both the classical beta(2)m-associated and beta(2)m-independent forms by members of the KIR and LILR families. Alternative recognition of different forms of HLA-B27 by leukocyte receptors could influence the function of cells from both innate and adaptive immune systems, and may indicate a role for various leukocyte populations in HLA-B27-associated inflammatory disease.
机构:John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England
Allen, RL
Bowness, P
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机构:John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England
Bowness, P
McMichael, AJ
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John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, EnglandJohn Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England
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Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Tech Univ Munich, Inst Microbiol, Trogerstr 32, D-81675 Munich, GermanyFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Bauer, Stefan
Groh, Veronika
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Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Groh, Veronika
Wu, Jun
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DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Wu, Jun
Steinle, Alexander
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Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Steinle, Alexander
Phillips, Joseph H.
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DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Phillips, Joseph H.
Lanier, Lewis L.
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DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Lanier, Lewis L.
Spies, Thomas
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Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
机构:
John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, EnglandJohn Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Bird, LA
Peh, CA
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Peh, CA
Kolinberger, S
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Kolinberger, S
Elliott, T
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Elliott, T
McMichael, AJ
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
McMichael, AJ
Bowness, P
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
机构:John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England
Allen, RL
Bowness, P
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h-index: 0
机构:John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England
Bowness, P
McMichael, AJ
论文数: 0引用数: 0
h-index: 0
机构:
John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, EnglandJohn Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Tech Univ Munich, Inst Microbiol, Trogerstr 32, D-81675 Munich, GermanyFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Bauer, Stefan
Groh, Veronika
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Groh, Veronika
Wu, Jun
论文数: 0引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Wu, Jun
Steinle, Alexander
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Steinle, Alexander
Phillips, Joseph H.
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h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Phillips, Joseph H.
Lanier, Lewis L.
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h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Lanier, Lewis L.
Spies, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USAFred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
机构:
John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, EnglandJohn Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Bird, LA
Peh, CA
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Peh, CA
Kolinberger, S
论文数: 0引用数: 0
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Kolinberger, S
Elliott, T
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h-index: 0
机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
Elliott, T
McMichael, AJ
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England
McMichael, AJ
Bowness, P
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机构:John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England