Targeting liver X receptors in cancer therapeutics

被引：167

作者：

Lin, Chin-Yo ^{[1
]}

Gustafsson, Jan-Ake ^{[1
,2
]}

机构：

[1] Univ Houston, Dept Biol & Biochem, Ctr Nucl Receptors & Cell Signaling, Houston, TX 77204 USA

[2] Karolinska Inst, Novum, Dept Biosci & Nutr, SE-14183 Huddinge, Sweden

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 04期

关键词：

HUMAN BREAST-CANCER; PROSTATE-CANCER; LXR-BETA; NUCLEAR RECEPTOR; RETINOID-X; GLUCOCORTICOID-RECEPTOR; CELL-PROLIFERATION; AGONIST T0901317; ACTIVATION; BINDING;

D O I：

10.1038/nrc3912

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses. There is now accumulating evidence to support the involvement of LXRs in a variety of malignancies and the potential efficacy of their ligands in these diseases. This Review summarizes the discovery and characterization of LXRs and their ligands, their effects and mechanisms in preclinical cancer models, and the future directions of basic and translational LXR research in cancer therapeutics.

引用

页码：216 / 224

页数：9

共 102 条

[1]

Activation of Liver X Receptors Inhibits Hedgehog Signaling, Clonogenic Growth, and Self-Renewal in Multiple Myeloma [J].

Agarwal, Jasmin R. ;

Wang, Qiuju ;

Tanno, Toshihiko ;

Rasheed, Zeshaan ;

Merchant, Akil ;

Ghosh, Nilanjan ;

Borrello, Ivan ;

Huff, Carol Ann ;

Parhami, Farhad ;

Matsui, William .

MOLECULAR CANCER THERAPEUTICS, 2014, 13 (07) :1873-1881

[2]

Estrogen receptor alpha in human breast cancer: Occurrence and significance [J].

Ali, S ;

Coombes, RC .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2000, 5 (03) :271-281

[3]

A NOVEL ORPHAN RECEPTOR-SPECIFIC FOR A SUBSET OF THYROID HORMONE-RESPONSIVE ELEMENTS AND ITS INTERACTION WITH THE RETINOID/THYROID HORMONE-RECEPTOR SUBFAMILY [J].

APFEL, R ;

BENBROOK, D ;

LERNHARDT, E ;

ORTIZ, MA ;

SALBERT, G ;

PFAHL, M .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (10) :7025-7035

[4]

Simultaneous activation of the liver X receptors (LXRα and LXRβ) drives murine collagen-induced arthritis disease pathology [J].

Asquith, Darren L. ;

Miller, Ashley M. ;

Reilly, James ;

Kerr, Shauna ;

Welsh, Paul ;

Sattar, Naveed ;

McInnes, Iain B. .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (12) :2225-2228

[5]

Auwerx J, 1999, CELL, V97, P161

[6]

Identification of 5α,6α-Epoxycholesterol as a Novel Modulator of Liver X Receptor Activity [J].

Berrodin, Thomas J. ;

Shen, Qi ;

Quinet, Elaine M. ;

Yudt, Matthew R. ;

Freedman, Leonard P. ;

Nagpal, Sunil .

MOLECULAR PHARMACOLOGY, 2010, 78 (06) :1046-1058

[7]

Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses [J].

Birrell, Mark A. ;

Catley, Matthew C. ;

Hardaker, Elizabeth ;

Wong, Sissie ;

Willson, Timothy M. ;

McCluskie, Kerryn ;

Leonard, Thomas ;

Farrow, Stuart N. ;

Collins, Jon L. ;

Haj-Yahia, Saleem ;

Belvisi, Maria G. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (44) :31882-31890

[8]

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor α in Mouse Liver Reveals Extensive Sharing of Binding Sites [J].

Boergesen, Michael ;

Pedersen, Thomas Askov ;

Gross, Barbara ;

van Heeringen, Simon J. ;

Hagenbeek, Dik ;

Bindesboll, Christian ;

Caron, Sandrine ;

Lalloyer, Fanny ;

Steffensen, Knut R. ;

Nebb, Hilde I. ;

Gustafsson, Jan-Ake ;

Stunnenberg, Hendrik G. ;

Staels, Bart ;

Mandrup, Susanne .

MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (04) :852-867

[9]

Antiproliferative Effects and Mechanisms of Liver X Receptor Ligands in Pancreatic Ductal Adenocarcinoma Cells [J].

Candelaria, Nicholes R. ;

Addanki, Sridevi ;

Zheng, Jine ;

Trang Nguyen-Vu ;

Karaboga, Husna ;

Dey, Prasenjit ;

Gabbi, Chiara ;

Vedin, Lise-Lotte ;

Liu, Ka ;

Wu, Wanfu ;

Jonsson, Philip K. ;

Lin, Jean Z. ;

Su, Fei ;

Bollu, Lakshmi Reddy ;

Hodges, Sally E. ;

McElhany, Amy L. ;

Issazadeh, Mehdi A. ;

Fisher, William E. ;

Ittmann, Michael M. ;

Steffensen, Knut R. ;

Gustafsson, Jan-Ake ;

Lin, Chin-Yo .

PLOS ONE, 2014, 9 (09)

[10]

Genome-wide analysis of estrogen receptor binding sites [J].

Carroll, Jason S. ;

Meyer, Clifford A. ;

Song, Jun ;

Li, Wei ;

Geistlinger, Timothy R. ;

Eeckhoute, Jerome ;

Brodsky, Alexander S. ;

Keeton, Erika Krasnickas ;

Fertuck, Kirsten C. ;

Hall, Giles F. ;

Wang, Qianben ;

Bekiranov, Stefan ;

Sementchenko, Victor ;

Fox, Edward A. ;

Silver, Pamela A. ;

Gingeras, Thomas R. ;

Liu, X. Shirley ;

Brown, Myles .

NATURE GENETICS, 2006, 38 (11) :1289-1297

← 1 2 3 4 5 6 7 8 9 10 →