Exposing asymmetry between monomers in Alzheimer's amyloid fibrils via reductive alkylation of lysine residues

被引：13

作者：

Iwata, K

Eyles, SJ

Lee, JP

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 123卷 / 27期

关键词：

D O I：

10.1021/ja015735y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：6728 / 6729

页数：2

共 17 条

[1] Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of β-sheets in Alzheimer's β-amyloid fibrils [J].

Antzutkin, ON ;

Balbach, JJ ;

Leapman, RD ;

Rizzo, NW ;

Reed, J ;

Tycko, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13045-13050

[2] Two-dimensional structure of β-amyloid(10-35) fibrils [J].

Benzinger, TLS ;

Gregory, DM ;

Burkoth, TS ;

Miller-Auer, H ;

Lynn, DG ;

Botto, RE ;

Meredith, SC .

BIOCHEMISTRY, 2000, 39 (12) :3491-3499

[3] Propagating structure of Alzheimer's β-amyloid(10-35) is parallel β-sheet with residues in exact register [J].

Benzinger, TLS ;

Gregory, DM ;

Burkoth, TS ;

Miller-Auer, H ;

Lynn, DG ;

Botto, RE ;

Meredith, SC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13407-13412

[4] INVITRO FORMATION OF AMYLOID FIBRILS FROM 2 SYNTHETIC PEPTIDES OF DIFFERENT LENGTHS HOMOLOGOUS TO ALZHEIMERS-DISEASE BETA-PROTEIN [J].

CASTANO, EM ;

GHISO, J ;

PRELLI, F ;

GOREVIC, PD ;

MIGHELI, A ;

FRANGIONE, B .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 141 (02) :782-789

[5] Molecular modeling of the Aβ1-42 peptide from Alzheimer's disease [J].

Chaney, MO ;

Webster, SD ;

Kuo, YM ;

Roher, AE .

PROTEIN ENGINEERING, 1998, 11 (09) :761-767

[6] In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics [J].

Esler, WP ;

Stimson, ER ;

Ghilardi, JR ;

Vinters, HV ;

Lee, JP ;

Mantyh, PW ;

Maggio, JE .

BIOCHEMISTRY, 1996, 35 (03) :749-757

[7] ALZHEIMERS-DISEASE AND DOWNS-SYNDROME - SHARING OF A UNIQUE CEREBROVASCULAR AMYLOID FIBRIL PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 122 (03) :1131-1135

[8] STRUCTURE OF BETA-CRYSTALLITE ASSEMBLIES FORMED BY ALZHEIMER BETA-AMYLOID PROTEIN ANALOGS - ANALYSIS BY X-RAY-DIFFRACTION [J].

INOUYE, H ;

FRASER, PE ;

KIRSCHNER, DA .

BIOPHYSICAL JOURNAL, 1993, 64 (02) :502-519

[9]

JENTOFT N, 1983, METHOD ENZYMOL, V91, P570

[10] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

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