The incidence of Lynch syndrome

被引：139

作者：

de la Chapelle, A ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Human Canc Genet Program, Columbus, OH 43210 USA

来源：

FAMILIAL CANCER | 2005年 / 4卷 / 03期

关键词：

frequency; hereditary nonpolyposis colorectal cancer; incidence; Lynch syndrome; mismatch repair gene mutations; prevalence;

D O I：

10.1007/s10689-004-5811-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lynch syndrome (LS) here is defined as carriership of a deleterious mismatch repair (MMR) gene mutation. By screening for MMR gene mutations in unselected colorectal or endometrial cancer patients, it was found that the prevalence of LS in colorectal and endometrial cancer patients is 1-3%. On extrapolation to the entire population, the incidence of LS is between 1:2000 and 1:660. As all screening methods are less than 100% sensitive, the above figures are underestimates.

引用

页码：233 / 237

页数：5

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