Clinical implementation of islet transplantation: A current assessment

被引:11
作者
Bottino, Rita [1 ]
Trucco, Massimo [1 ]
机构
[1] Allegheny Hlth Network, Inst Cellular Therapeut, Pittsburgh, PA 15212 USA
关键词
diabetes; islet transplantation; pancreas transplantation; CELL SECRETORY CAPACITY; TOTAL PANCREATECTOMY; DIABETES-MELLITUS; NONHUMAN-PRIMATES; GLYCEMIC CONTROL; PORCINE ISLETS; PANCREAS; XENOTRANSPLANTATION; AUTOTRANSPLANTATION; OUTCOMES;
D O I
10.1111/pedi.12287
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Beta-cell replacement is the only physiologically relevant alternative to insulin injections in patients with type 1 diabetes (T1D). Pancreas and islet transplantation from deceased organ donors can provide a new beta-cell pool to produce insulin, help blood glucose management, and delay secondary diabetes complications. For children and adolescents with T1D, whole pancreas transplantation is not a viable option because of surgical complications, whereas islet transplantation, even if it is procedurally simpler, must still overcome the burden of immunosuppression to become a routine therapy for children in the future.
引用
收藏
页码:393 / 401
页数:9
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