Clinical implementation of islet transplantation: A current assessment

被引：11

作者：

Bottino, Rita ^{[1
]}

Trucco, Massimo ^{[1
]}

机构：

[1] Allegheny Hlth Network, Inst Cellular Therapeut, Pittsburgh, PA 15212 USA

来源：

PEDIATRIC DIABETES | 2015年 / 16卷 / 06期

关键词：

diabetes; islet transplantation; pancreas transplantation; CELL SECRETORY CAPACITY; TOTAL PANCREATECTOMY; DIABETES-MELLITUS; NONHUMAN-PRIMATES; GLYCEMIC CONTROL; PORCINE ISLETS; PANCREAS; XENOTRANSPLANTATION; AUTOTRANSPLANTATION; OUTCOMES;

D O I：

10.1111/pedi.12287

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Beta-cell replacement is the only physiologically relevant alternative to insulin injections in patients with type 1 diabetes (T1D). Pancreas and islet transplantation from deceased organ donors can provide a new beta-cell pool to produce insulin, help blood glucose management, and delay secondary diabetes complications. For children and adolescents with T1D, whole pancreas transplantation is not a viable option because of surgical complications, whereas islet transplantation, even if it is procedurally simpler, must still overcome the burden of immunosuppression to become a routine therapy for children in the future.

引用

页码：393 / 401

页数：9

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