Platelet serotonergic predictors of clinical improvement in obsessive compulsive disorder

被引:17
作者
Delorme, R
Chabane, N
Callebert, J
Falissard, B
Mouren-Siméoni, MC
Rouillon, F
Launay, JM
Leboyer, M
机构
[1] Hop Robert Debre, Serv Psychopathol Enfant & Adolescent, AP HP, F-75019 Paris, France
[2] Fac Paris 12, INSERM, U 513, Creteil, France
[3] Hop Lariboisiere, AP HP, CRC Bernard, Serv Biochim,IFR 6, F-75475 Paris, France
[4] Hop Paul Brousse, Unite Sante Publ, Villejuif, France
[5] Hop Henri Mondor & Albert Chenevier, AP HP, Psychiat Serv, Creteil, France
关键词
D O I
10.1097/01.jcp.0000104905.75206.50
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: Serotonin reuptake inhibitors (SRls) are the most efficient pharmacological treatment of obsessive-compulsive disorders (OCD). Previous studies have suggested that some peripheral serotonergic parameters can be used to predict the clinical outcome of the treatment of OCD patients with SRls. We tried to identify further peripheral serotonergic parameters that could help predict the clinical outcome of SRI treatment in a sample of patients with OCD. Methods: We compared 19 OCD patients before and after 8 weeks of SRI treatment with 19 sex-matched and age-matched controls. We assessed clinical improvement and whole-blood serotonin (5-HT) concentration, platelet 5-HT transporter (5-HTT) and 5-HT2A receptor binding characteristics and platelet IP3 content. Results: Before treatment, OCD patients had higher platelet IP3 content and fewer 5-HTT binding sites than the controls. Treatment with SRls further lowered the number of 5-HTT binding sites, normalized platelet IP3 contents, and lowered the number of platelet 5-HT2A binding sites and whole-blood 5-HT concentrations below control values. The patients who improved most following SRI treatment had higher whole-blood 5-HT concentrations before treatment. Conclusion: Our results confirm that whole-blood 5-HT concentration is a predictor for clinical improvement and indicate that abnormal intracellular mechanisms may be involved in OCD patients, in particular, the overstimulation of the phosphoinositide signaling system.
引用
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页码:18 / 23
页数:6
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