Autoimmune pathogenesis and autoimmune hemolytic anemia

被引：43

作者：

Semple, JW

Freedman, J

机构：

[1] St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada

[2] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[3] Univ Toronto, Dept Med, Toronto, ON, Canada

[4] Univ Toronto, Lab Med & Pathobiol, Toronto, ON, Canada

[5] Canadian Blood Serv, Toronto, ON, Canada

[6] Toronto Platelet Immunobiol Grp, Toronto, ON, Canada

来源：

SEMINARS IN HEMATOLOGY | 2005年 / 42卷 / 03期

关键词：

D O I：

10.1053/j.seminhematol.2005.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which autoantibodies are directed against an individual's own red blood cells (RBCs), leading to enhanced clearance through Fc receptor (FcR)-mediated phagocytosis. Although there is a large literature relating to clinical aspects of AIHA, relatively little work addresses how IgG autoantibodies are actually produced against RBC autoantigens. This review will first discuss the current understanding of autoimmunity in general and then focus on the knowledge of the immunopathogenic mechanisms responsible for autoantibody production in AIHA. Both human and animal studies will be discussed. Understanding theses mechanism is vital for developing antigen-specific immunotherapies to treat the disease. © 2005 Elsevier Inc. All rights reserved.

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收藏

页码：122 / 130

页数：9

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