Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol

被引：25

作者：

Carland, M

Tan, KJ

White, JM

Stephenson, J

Murray, V

Denny, WA

McFadyen, WD ^{[1
]}

机构：

[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

[2] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[3] Univ Auckland, Auckland Canc Soc Res Ctr, Fac Med & Hlth Sci, Auckland 1, New Zealand

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 08期

基金：

英国医学研究理事会;

关键词：

diamineplatinum(II); maltolate; synthesis; structure; cytotoxicity;

D O I：

10.1016/j.jinorgbio.2005.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The cationic complexes (1,2-diaminoethane)(maltolato)platinum(II) ([Pt(en)(ma)](+)) and(1R,2R-1,2-diaminocyclohexane)(maltolato)platinum(II) ([Pt(R,R-DACH)(ma)](+)) have been prepared and the structure of [Pt(R,R-DACH)(ma)]NO3 has been determined by single crystal X-ray diffraction. The geometry of the metal in [Pt(R,R-DACH)(ma)]NO3 is essentially square planar and the maltolate ligand has a geometry similar to other chelate complexes involving this ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and the IC50 values are approximately 32 mu M in HeLa cells and 26 mu M in K562 cells. In these cell lines the cytotoxicity of cisplatin is higher than the maltolate complexes by a factor of 2 to 3 whereas the cytotoxicity of carboplatin is lower than the maltolate complexes. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1738 / 1743

页数：6

共 19 条

[1]

The structures of bis-maltolato-zinc(II) and of bis-3-hydroxy-1,2-dimethyl-4-pyridinonato-zinc (II) and -lead(II) [J].