Proteolipid protein gene - Pelizaeus-Merzbacher disease in humans and neurodegeneration in mice

被引：30

作者：

Woodward, K ^{[1
]}

Malcolm, S ^{[1
]}

机构：

[1] Inst Child Hlth, Mol Genet Unit, London WC1N 1EH, England

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0168-9525(99)01716-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The dosage of the myelin gene and mutant forms of the protein can affect the CNS and PNS. Pelizaeus-Merzbacher disease (PMD) is a myelin disorder of the CNS that arises from both mutational mechanisms. Investigating the molecular basis of PMD in patients and animal models is furthering our understanding of the disease, dosage sensitivity and proteolipid protein function during myelinogenesis.

引用

页码：125 / 128

页数：4

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