The Centrosome in Cells and Organisms

被引：350

作者：

Bornens, Michel ^{[1
]}

机构：

[1] Inst Curie, Ctr Natl Rech Sci, UMR144, F-75248 Paris 05, France

来源：

SCIENCE | 2012年 / 335卷 / 6067期

关键词：

CENTRIOLE; ORGANIZATION; POLARIZATION; CILIOGENESIS; INHERITANCE; COMPONENTS; MIGRATION; CLEAVAGE; SYMMETRY; DIVISION;

D O I：

10.1126/science.1209037

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The centrosome acts as the main microtubule-nucleating organelle in animal cells and plays a critical role in mitotic spindle orientation and in genome stability. Yet, despite its central role in cell biology, the centrosome is not present in all multicellular organisms or in all cells of a given organism. The main outcome of centrosome reproduction is the transmission of polarity to daughter cells and, in most animal species, the sperm-donated centrosome defines embryo polarity. Here I will discuss the role of the centrosome in cell polarity, resulting from its ability to position the nucleus at the cell center, and discuss how centrosome innovation might have been critical during metazoan evolution.

引用

页码：422 / 426

页数：5

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