Fatty acid oxidation affects food intake by altering hepatic energy status

被引:87
作者
Friedman, MI [1 ]
Harris, RB [1 ]
Ji, H [1 ]
Ramirez, I [1 ]
Tordoff, MG [1 ]
机构
[1] Monell Chem Senses Ctr, Philadelphia, PA 19104 USA
关键词
feeding behavior; metabolism; liver; adenosine 5 '-triphosphate; methyl palmoxirate;
D O I
10.1152/ajpregu.1999.276.4.R1046
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Inhibition of fatty acid oxidation stimulates feeding behavior in rats. To determine whether a decrease in hepatic fatty acid oxidation triggers this behavioral response, we compared the effects of different doses of methyl palmoxirate (MP), an inhibitor of fatty acid oxidation, on food intake with those on in vivo and in vitro liver and muscle metabolism. Administration of 1 mg/kg MP selectively decreased hepatic fatty acid oxidation but did not stimulate food intake. in contrast, feeding behavior increased in rats given 5 or 10 mg/kg MP, which inhibited hepatic fatty acid oxidation to the same extent as did the low dose but in addition suppressed fatty acid oxidation in muscle and produced a marked depletion of liver glycogen. Dose-related increases in food intake tracked dose-related reductions in liver ATP content, ATP-to-ADP ratio, and phosphorylation potential. The findings suggest that a decrease in hepatic fatty acid oxidation can stimulate feeding behavior by reducing hepatic energy production.
引用
收藏
页码:R1046 / R1053
页数:8
相关论文
共 35 条