Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth

被引:57
作者
Shibata, T
Kawano, T
Nagayasu, H
Okumura, K
Arisue, M
Hamada, J
Takeichi, N
Hosokawa, M
机构
[1] HOKKAIDO UNIV,SCH MED,INST CANC,CELL BIOL LAB,SAPPORO,HOKKAIDO 060,JAPAN
[2] HOKKAIDO UNIV,SCH MED,INST CANC,PATHOL LAB,SAPPORO,HOKKAIDO 060,JAPAN
关键词
epidermal growth factor; squamous cell carcinoma; oral cancer; invasion;
D O I
10.1159/000217979
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In order to ascertain the effects of epidermal growth factor (EGF) on human cancer invasion abilities, three cell lines of human oral squamous cell carcinoma were studied using a phagokinetic track assay and zymography. EGF(1-100 ng/ml) was found to inhibit the growth but enhance the random motility of all three cell lines in a concentration-dependent fashion. Exposure to EGF, dose-dependently, led to an increased production of urokinase-type plasminogen activator and M(r) 92 kD matrix metalloproteinase by the same cells, These results strongly suggest that EGF may promote human squamous cell carcinoma invasion and metastasis.
引用
收藏
页码:168 / 175
页数:8
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