The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides

被引：32

作者：

Hernandez, Armando R. ^{[1
]}

Kool, Eric T. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

NUCLEOTIDE ANALOGS; RNA; BENZOINOSINE; MECHANISM; PROBES; SITES;

D O I：

10.1021/ol102915f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369-411 nm. The compounds are expected to be useful as RNA pathway probes and as components of an unnatural ribopolymer.

引用

页码：676 / 679

页数：4

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