Mechanical hyperalgesia in complex regional pain syndrome:: A role for TNF-α?

被引：83

作者：

Maihöfner, C

Handwerker, HO

Neundörfer, B

Birklein, F

机构：

[1] Univ Erlangen Nurnberg, Inst Physiol & Expt Pathophysiol, Dept Neurol, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Physiol & Expt Pathophysiol, D-91054 Erlangen, Germany

来源：

NEUROLOGY | 2005年 / 65卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000168866.62086.8f

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Plasma concentrations of soluble tumor necrosis factor alpha (TNF-alpha) receptor type I (sTNF-RI) were assessed in two complex regional pain syndrome (CRPS) patient groups (n = 30 and n = 16) and healthy controls (n = 25). Patients with CRPS and mechanical hyperalgesia had higher levels of sTNF-RI (1,661.8 +/- 146.8 pg/mL) compared with those with CRPS with identical clinical appearance but without hyperalgesia (1,155.9 +/- 56.3 pg/mL) and controls (1,239.5 +/- 42.9 pg/mL). This study suggests involvement of TNF-alpha in mechanical hyperalgesia of CRPS.

引用

页码：311 / 313

页数：3

共 10 条

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