Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS

被引：58

作者：

Goddard, DR ^{[1
]}

Bunning, RAD ^{[1
]}

Woodroofe, MN ^{[1
]}

机构：

[1] Sheffield Hallam Univ, Div Biomed Sci, Sch Sci & Math, Sheffield S1 1WB, S Yorkshire, England

来源：

GLIA | 2001年 / 34卷 / 04期

关键词：

glia; sheddase; TNF-alpha; protease; cytokine;

D O I：

10.1002/glia.1060

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ADAM 17, also known as TACE, is an important sheddase for a number of proteins, including tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-alpha (TGF-alpha), L-selectin, p75, and p55 TNF receptors, and interleukin-l receptor II (IL-1RII). The presence of ADAM 17 mRNA in adult mouse and rat CNS was recently reported (Karkkainen et al. Mol Cell Neurosci 15:547-560, 2000). However, the cellular origin of ADAM 17 remains unknown. In this study, we have used an anti-ADAM 17 antibody in an immunohistochemical study of its distribution in human adult CNS tissue. Cells with astrocytic and endothelial morphology were ADAM 17-positive. This finding was further confirmed using double immunofluorescence with antibodies against GFAP and von Willebrand factor, which label astrocytes and endothelial cells, respectively. This study demonstrates that ADAM 17 is expressed by astrocytes and endothelial cells in normal brain tissue and may have a role in normal brain function. (C) 2001 Wiley-Liss, Inc.

引用

页码：267 / 271

页数：5

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