Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein

被引：10

作者：

Ishida, T ^{[1
]}

Tasaki, K ^{[1
]}

Fukuda, A ^{[1
]}

Ishii, Y ^{[1
]}

Oguri, K ^{[1
]}

机构：

[1] Kyushu Univ, Fac Pharmaceut Sci, Higashi Ku, Fukuoka 8128582, Japan

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 1998年 / 6卷 / 04期

基金：

日本学术振兴会;

关键词：

antioxidant; induction; acetaminophen; selenium; acetaminophen-binding protein; selenium-binding;

D O I：

10.1016/S1382-6689(98)00042-8

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We have previously shown that a 54 kDa protein in rat liver is highly homologous to selenium-binding protein (SeBP) or acetaminophen-binding protein (APBP) in mice and is highly inducible by treatment with 3,3',4,4',5-pentachlorobiphenyl or 3-methylcholanthrene. In this study, we examine the effect of six typical inducers, 3-methylcholanthrene (MC), isosafrole (ISO), phenobarbital (PB), dexamethasone (DES), clofibrate (CLO), pyrazole (PYR) and butylated hydroxytoluene (BHT), on the expression level of this 54 kDa protein. Male Wistar rats were given each inducer following a predetermined schedule. Among these inducers, the 54 kDa protein was inducible by MC and BHT. The response to MC and BHT was compared with that of NAD(P)H: quinone oxidoreductase and ethoxyresorufin O-deethylase activities. The induction mechanisms and physiological role of the 54 kDa protein are discussed in the light of our results. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：249 / 255

页数：7

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