The behavioral functions of the cholinergic basal forebrain: Lessons from 192 IgG-SAPORIN

Until recently, our understanding of the functional neuroanatomy of the cholinergic basal forebrain (CBF) has been hindered by the lack of a lesioning technique that is truly selective. The development of the immunotoxin 192 IgG-saporin (192-sap) has greatly improved our ability to create specific lesions of the CBF, Rats with such lesions have been studied in a wide variety of behavioral paradigms of learning, memory, and attention. Complete or near-complete destruction of the CBF results in deficits in a variety of behavior paradigms including passive avoidance, spatial tasks (water and radial mazes), delayed matching to position/sample, and attentional tasks. However, interpretation of many experiments is hampered by incomplete lesions and/or concomitant damage to cerebellar Purkinje neurons. Future studies will need to address these issues. Recent development of a similar immunotoxin that is effective in primates should permit more sophisticated behavioral analysis of CBF function. Additionally, immunotoxins selective for other types of neurons, such as the noradrenergic selective anti-DBH-saporin, will permit analysis of the behavioral functions of other diffusely projecting systems and how these other systems may interact with the CBF. (C) 1999 ISDN. Published by Elsevier Science Ltd. All rights reserved.