Microbleeds relate to altered amyloid-beta metabolism in Alzheimer's disease

被引：58

作者：

Goos, Jeroen D. C. ^{[1
,2
]}

Teunissen, Charlotte E. ^{[2
,3
]}

Veerhuis, Robert ^{[2
,3
]}

Verwey, Nicolaas A. ^{[1
,2
,3
]}

Barkhof, Frederik ^{[2
,4
]}

Blankenstein, Marinus A. ^{[2
,3
]}

Scheltens, Philip ^{[1
,2
]}

van der Flier, Wiesje M. ^{[1
,2
,5
,6
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Radiol, NL-1007 MB Amsterdam, Netherlands

[5] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol, NL-1007 MB Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Med Ctr, Dept Biostat, NL-1007 MB Amsterdam, Netherlands

来源：

NEUROBIOLOGY OF AGING | 2012年 / 33卷 / 05期

关键词：

Alzheimer's disease; Vascular dementia; Cerebral amyloid angiopathy; MRI; Cerebrospinal fluid; MILD COGNITIVE IMPAIRMENT; TEMPORAL-LOBE ATROPHY; CEREBROSPINAL-FLUID; CLINICAL-DIAGNOSIS; VASCULAR DEMENTIA; ANGIOPATHY; PLASMA; PATHOLOGY; CSF; QUANTIFICATION;

D O I：

10.1016/j.neurobiolaging.2011.10.026

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cerebral microbleeds (MBs) may relate to amyloid in dementia. We selected 26 probable Alzheimer's disease (AD) patients with MBs, 26 age- and sex-matched AD patients without MBs, 11 vascular dementia (VaD) patients, and 22 patients with subjective complaints. We measured amyloid beta 1-42 (A beta 42) and 1-40 (A(340) in cerebrospinal fluid (CSF) and plasma, and blood-brain barrier (BBB) function using albumin ratios. CSF A beta 42 was lowest in AD with MBs, whereas A beta 40 was selectively decreased in VaD. In plasma, amyloid-beta was nonsignificantly elevated in VaD compared with controls. Higher albumin ratios in VaD suggested blood-brain barrier dysfunction. A MB pattern suggestive of cerebral amyloid angiopathy (CAA) related to lower CSF A beta 42, while a non-cerebral amyloid angiopathy specific MB distribution related to higher plasma A beta 40. Amyloid-beta is differentially implicated in AD with MBs and VaD. MB distribution related to different amyloid profiles, supporting distinct etiologies. Our results suggest that A beta 42 is retained in cerebrovasculature of AD patients with MBs, while in contrast. VaD patients may possibly drain amyloid. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1011.e1 / 1011.e9

页数：9

共 42 条

[1] Progression of cerebral amyloid angiopathy:: Accumulation of amyloid-β40 in affected vessels [J].