Elevated plasma levels of transforming growth factor β1 in patients with muscular dystrophy

被引：48

作者：

Ishitobi, M

Haginoya, K ^{[1
]}

Zhao, YJ

Ohnuma, A

Minato, J

Yanagisawa, T

Tanabu, M

Kikuchi, M

Iinuma, K

机构：

[1] Tohoku Univ, Sch Med, Dept Pediat, Sendai, Miyagi 9808574, Japan

[2] Takutou Rehabil Ctr Disabled Children, Dept Pediat, Sendai, Miyagi, Japan

[3] China Med Univ, Clin Coll 2, Dept Pediat, Shenyang, Peoples R China

[4] Fukushima Hosp Handicapped Children, Dept Orthoped & Pediat, Iwaki, Fukushima, Japan

[5] Hachinohe Municipal Hosp, Dept Pediat, Hachinohe, Japan

[6] Hitachi Gen Hosp, Dept Pediat, Hitachi, Ibaraki, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 18期

关键词：

ELISA; fibrosis; muscular dystrophy; transforming growth factor;

D O I：

10.1097/00001756-200012180-00026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The progression of muscular weakness of patients suffering from muscular dystrophies directly correlates with the progressive loss of myofibers, accompanied by fibrosis. Since transforming growth factor beta1 (TGF-beta1) promotes tissue fibrosis, we measured the plasma TGF-beta1 level in patients with various muscular dystrophies in order to determine whether the level is elevated in patients with muscular dystrophy and if the level reflects the severity of tissue fibrosis. The plasma TGF-beta1 level was significantly elevated in patients with Duchenne muscular dystrophy and congenital muscular dystrophy (CMD), but not in those with Becker muscular dystrophy. Growth factors related to muscle fiber regeneration and fibrosis might be a key factor in the progression of muscular dystrophy and could be a target for therapeutic studies. NeuroReport 11:4033-4035 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：4033 / 4035

页数：3

共 19 条

[1] Transforming growth factor-β1 and fibrosis in congenital muscular dystrophies [J].