TGF-β receptors: In and beyond TGF-β signaling

被引：354

作者：

Ark, Alexandra Vander ^{[1
]}

Cao, Jingchen ^{[1
]}

Li, Xiaohong ^{[1
]}

机构：

[1] Van Andel Res Inst, Ctr Canc & Cell Biol, Grand Rapids, MI 49503 USA

来源：

CELLULAR SIGNALLING | 2018年 / 52卷

关键词：

Transforming growth factor beta (TGF-beta); TGF-beta receptor (TGFBR); SMAD; Phosphorylation; Ubiquitination; Endocytosis; TRANSFORMING-GROWTH-FACTOR; PROTEIN-COUPLED RECEPTORS; EPITHELIAL-MESENCHYMAL TRANSITION; II RECEPTOR; CORE FUCOSYLATION; EXPRESSION CLONING; SOLUBLE BETAGLYCAN; ENDOTHELIAL-CELLS; PROSTATE-CANCER; DOWN-REGULATION;

D O I：

10.1016/j.cellsig.2018.09.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Transforming growth factor (TGF-beta) plays an important role in normal development and homeostasis. Dysregulation of TGF-beta responsiveness and its downstream signaling pathways contribute to many diseases, including cancer initiation, progression, and metastasis. TGF-beta ligands bind to three isoforms of the TGF-beta receptor (TGFBR) with different affinities. TGFBR1 and 2 are both serine/threonine and tyrosine kinases, but TGFBR3 does not have any kinase activity. They are necessary for activating canonical or noncanonical signaling pathways, as well as for regulating the activation of other signaling pathways. Another prominent feature of TGF-beta signaling is its context-dependent effects, temporally and spatially. The diverse effects and context dependency are either achieved by fine-tuning the downstream components or by regulating the expressions and activities of the ligands or receptors. Focusing on the receptors in events in and beyond TGF-beta signaling, we review the membrane trafficking of TGFBRs, the kinase activity of TGFBR1 and 2, the direct interactions between TGFBR2 and other receptors, and the novel roles of TGFBR3.

引用

页码：112 / 120

页数：9

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