Effect of Hibiscus sabdariffia on obesity in MSG mice

被引:101
作者
Alarcon-Aguilar, Francisco J. [1 ]
Zamilpa, Alejandro
Perez-Garcia, Ma. Dolores
Almanza-Perez, Julio C.
Romero-Nunez, Eunice
Campos-Sepulveda, Efrain A.
Vazquez-Carrillo, Laura I.
Roman-Ramos, Ruben
机构
[1] Univ Autonoma Metropolitana Iztapalapa, Dpto Ciencias Salud DCBS, Farmacol Lab, Iztapalapa, Mexico
[2] Inst Mexicano Seguro Social, Ctr Invest Biomed Sur, Xochitepec, Mexico
[3] Univ Nacl Autonoma Mexico, Fac Med, Dept Farmacol, Toxicol Lab, Mexico City 04510, DF, Mexico
关键词
hibiscus sabdariffa; obesity; anthocyanins; medicinal plants; anti-obesity plants; edible plant Malvaceae;
D O I
10.1016/j.jep.2007.07.020
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The aim of the present investigation was determine whether a standardized Hibiscus sabdariffa calyces aqueous extract has an effect on body weight in an obese animal model induced by the administration of monosodium, glutamate. Hibiscus sabdariffa aqueous extract, containing 33.64 mg of total anthocyanins per each 120 mg of extract, was orally administered (120 mg/kg/day) for 60 days to healthy and obese mice, and body weight gain, food and liquid intake, aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol, and triglycerides levels were measured. Hibiscus sabdariffa administration significantly reduced body weight gain in obese mice and increased liquid intake in healthy and obese mice. ALT levels were significantly increased on the 15th and 45th days in obese mice, but AST levels did not show significant changes. Mortality was not observed in the Hibiscus sabdariffa treated groups. Triglycerides and cholesterol levels showed non-significant reductions in animals treated with Hibiscus sabdariffa. Our data confirm the anti-obesity effect of Hibiscus sabdariffa reported by the Mexican population. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:66 / 71
页数:6
相关论文
共 31 条
[1]   Toxicological investigation of aqueous-methanolic extract of the calyces of Hibiscus sabdariffia L. [J].
Akindahunsi, AA ;
Olaleye, MT .
JOURNAL OF ETHNOPHARMACOLOGY, 2003, 89 (01) :161-164
[2]   Neuropharmacological effects of Hibiscus sabdariffa aqueous extract [J].
Amos, S ;
Binda, L ;
Chindo, BA ;
Tseja, A ;
Odutola, AA ;
Wambebe, C ;
Gamaniel, K .
PHARMACEUTICAL BIOLOGY, 2003, 41 (05) :325-329
[3]  
AQUINO YD, 2005, REV ELECT LATINOAMER, V17
[4]   INDUCTION OF OBESITY IN RODENTS BY MEANS OF MONOSODIUM GLUTAMATE [J].
BUNYAN, J ;
MURRELL, EA ;
SHAH, PP .
BRITISH JOURNAL OF NUTRITION, 1976, 35 (01) :25-39
[5]   Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat:: a preliminary report [J].
Calapai, G ;
Firenzuoli, F ;
Saitta, A ;
Squadrito, F ;
Arlotta, MR ;
Costantino, G ;
Inferrera, G .
FITOTERAPIA, 1999, 70 (06) :586-592
[6]   Strategies and potential molecular targets for obesity treatment [J].
Campfield, LA ;
Smith, FJ ;
Burn, P .
SCIENCE, 1998, 280 (5368) :1383-1387
[7]  
Campos-Sepulveda AE, 2002, P W PHARMACOL SOC, V45, P44
[8]   Screening of antibiotic resistant inhibitors from local plant materials against two different strains of Staphylococcus aureus [J].
Darwish, RA ;
Aburjai, T ;
Al-Khalil, S ;
Mahafzah, A .
JOURNAL OF ETHNOPHARMACOLOGY, 2002, 79 (03) :359-364
[9]  
*DIAR OF FED, 1999, NOM062ZOO1999 DIAR O
[10]   The effect of sour tea (Hibiscus sabdariffa) on essential hypertension [J].
Faraji, MH ;
Tarkhani, AHH .
JOURNAL OF ETHNOPHARMACOLOGY, 1999, 65 (03) :231-236