Innate pathogen recognition in the kidney: Toll-like receptors, NOD-like receptors, and RIG-like helicases

被引：28

作者：

Anders, H-J ^{[1
]}

机构：

[1] Univ Munich, Dept Nephrol, Med Policlin, Munich, Germany

来源：

KIDNEY INTERNATIONAL | 2007年 / 72卷 / 09期

关键词：

infection; inflammation; glomerulonephritis; kidney disease; interferon; IMMUNE-COMPLEX GLOMERULONEPHRITIS; DISEASE; CELLS; TOLL-LIKE-RECEPTOR-4; INFLAMMATION; EXPRESSION; INFECTION; PROTEINS; INJURY; LUPUS;

D O I：

10.1038/sj.ki.5002436

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

How do infections trigger or aggravate renal pathology? The discovery of the toll-like receptors, and more recently, the retinoic-acid-inducible protein-like helicases and the nucleotide-binding oligomerization domain-like receptors may offer new concepts to answer this question. Common pathogen-associated molecules are recognized by these receptors in several cellular compartments of immune cells and non-immune cells inside the kidney. This article summarizes ligand-receptor interactions and their known or potential significance in kidney diseases.

引用

页码：1051 / 1056

页数：6

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