Consumption of a DHA-containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration

被引:29
作者
Courville, Amber B. [1 ]
Harel, Ofer [2 ]
Lammi-Keefe, Carol J. [1 ,3 ,4 ]
机构
[1] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA
[2] Univ Connecticut, Dept Stat, Storrs, CT 06269 USA
[3] Louisiana State Univ, Ctr Agr, Baton Rouge, LA 70803 USA
[4] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70803 USA
关键词
DHA; Pregnancy; Ponderal index; Insulin; FATTY-ACID-COMPOSITION; BIRTH-WEIGHT; DOCOSAHEXAENOIC ACID; FETAL ORIGINS; SUPPLEMENTATION; ADIPONECTIN;
D O I
10.1017/S0007114511000961
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
DHA (22 : 6n-3) in pregnancy has previously been shown to benefit infant brain and retinal development. Fatty acid consumption during pregnancy may also have an impact on infant adipose tissue development. The objective of the present study was to assess the prenatal impact of a DHA-containing functional food (DHA-FF) on infant intra-uterine growth. This was a longitudinal, randomised, double-blinded, placebo-controlled trial. Pregnant women were assigned to consume a DHA-FF or placebo bar from 24 weeks' gestation until delivery. Blood samples were collected from mothers at baseline and delivery and from the umbilical cord at delivery. Plasma and erythrocyte fatty acids were analysed by GLC and plasma insulin concentrations were analysed using a commercially available ELISA kit. Infant birth weight and length were obtained at delivery and ponderal index (weight (g)/length (cm)(3) x 100) was calculated. A total of forty-seven mothers completed the study. Infants of mothers consuming the DHA-FF during the last half of pregnancy had lower ponderal indices (beta = 0.198, P<0.05) and umbilical cord blood insulin concentrations (beta = 0.743, P<0.05) than infants of mothers consuming the placebo. Thus, DHA consumption during pregnancy may be advantageous with respect to infant body composition at birth and insulin sensitivity.
引用
收藏
页码:208 / 212
页数:5
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