Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

被引：91

作者：

Omura, Takao ^{[1
,2
]}

Omura, Kumiko ^{[1
,2
]}

Tedeschi, Andrea ^{[1
,2
]}

Riva, Priscilla ^{[1
,2
]}

Painter, Michio W. ^{[1
,2
]}

Rojas, Leticia ^{[1
,2
]}

Martin, Joshua ^{[1
,2
]}

Lisi, Veronique ^{[3
]}

Huebner, Eric A. ^{[1
,2
]}

Latremoliere, Alban ^{[1
,2
]}

Yin, Yuqin ^{[1
,2
]}

Barrett, Lee B. ^{[1
,2
]}

Singh, Bhagat ^{[1
,2
]}

Lee, Stella ^{[1
,2
]}

Crisman, Tom ^{[4
]}

Gao, Fuying ^{[4
]}

Li, Songlin ^{[5
,6
]}

Kapur, Kush ^{[1
,2
]}

Geschwind, Daniel H. ^{[4
]}

Kosik, Kenneth S. ^{[3
]}

Coppola, Giovanni ^{[4
]}

He, Zhigang ^{[1
,2
]}

Carmichael, S. Thomas ^{[5
,6
]}

Benowitz, Larry I. ^{[1
,2
]}

Costigan, Michael ^{[1
,2
,7
]}

Woolf, Clifford J. ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Univ Calif Santa Barbara, Neurosci Res Inst, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Dept Psychiat & Neurol, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Dept Neurol, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Multiple Myeloma Res Consortium, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA

[7] Boston Childrens Hosp, Anaesthesia Dept, Boston, MA 02115 USA

来源：

NEURON | 2015年 / 86卷 / 05期

关键词：

SPINAL-CORD-INJURY; INTRINSIC GROWTH-STATE; CHONDROITIN SULFATE PROTEOGLYCAN; OPTIC-NERVE REGENERATION; DORSAL-ROOT GANGLIA; COLLABORATIVE CROSS; GENE-EXPRESSION; SENSORY NEURONS; ACTIVIN-A; RECEPTOR;

D O I：

10.1016/j.neuron.2015.05.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on CNS myelin than the other eight strains tested, especially when pre-injured. Injury-primed CAST/Ei neurons also regenerate markedly in the spinal cord and optic nerve more than those from C57BL/6 mice and show greater sprouting following ischemic stroke. Heritability estimates indicate that extended growth in CAST/Ei neurons on myelin is genetically determined, and two whole-genome expression screens yield the Activin transcript Inhba as most correlated with this ability. Inhibition of Activin signaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6 animals boosts regeneration. This screen demonstrates that mammalian CNS regeneration can occur and reveals a molecular pathway that contributes to this ability.

引用

页码：1215 / 1227

页数：13

共 57 条

[1]

Functional regeneration of respiratory pathways after spinal cord injury [J].

Alilain, Warren J. ;

Horn, Kevin P. ;

Hu, Hongmei ;

Dick, Thomas E. ;

Silver, Jerry .

NATURE, 2011, 475 (7355) :196-U95

[2]

Combinatorial treatments for promoting axon regeneration in the CNS: Strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state [J].

Benowitz, Larry I. ;

Yin, Yuqin .

DEVELOPMENTAL NEUROBIOLOGY, 2007, 67 (09) :1148-1165

[3]

Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: Superiority to camp-mediated effects [J].

Blesch, Armin ;

Lu, Paul ;

Tsukada, Shingo ;

Alto, Laura Taylor ;

Roet, Kasper ;

Coppola, Giovanni ;

Geschwind, Dan ;

Tuszynski, Mark H. .

EXPERIMENTAL NEUROLOGY, 2012, 235 (01) :162-173

[4]

FORMULATING ACCIDENT OCCURRENCE AS A SURVIVAL PROCESS [J].

CHANG, HL ;

JOVANIS, PP .

ACCIDENT ANALYSIS AND PREVENTION, 1990, 22 (05) :407-419

[5]

The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics [J].

Chesler, Elissa J. ;

Miller, Darla R. ;

Branstetter, Lisa R. ;

Galloway, Leslie D. ;

Jackson, Barbara L. ;

Philip, Vivek M. ;

Voy, Brynn H. ;

Culiat, Cymbeline T. ;

Threadgill, David W. ;

Williams, Robert W. ;

Churchill, Gary A. ;

Johnson, Dabney K. ;

Manly, Kenneth F. .

MAMMALIAN GENOME, 2008, 19 (06) :382-389

[6]

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration [J].

Cho, Yongcheol ;

Sloutsky, Roman ;

Naegle, Kristen M. ;

Cavalli, Valeria .

CELL, 2013, 155 (04) :894-908

[7]

Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model [J].

Clarkson, Andrew N. ;

Lopez-Valdes, Hector E. ;

Overman, Justine J. ;

Charles, Andrew C. ;

Brennan, K. C. ;

Carmichael, S. Thomas .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (05) :716-723

[8]

Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. [J].

Costigan, Michael ;

Befort, Katia ;

Karchewski, Laurie ;

Griffin, Robert S. ;

D'Urso, Donatella ;

Allchorne, Andrew ;

Sitarski, Joanne ;

Mannion, James W. ;

Pratt, Richard E. ;

Woolf, Clifford J. .

BMC NEUROSCIENCE, 2002, 3 (1)

[9]

Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1 [J].

Costigan, Michael ;

Belfer, Inna ;

Griffin, Robert S. ;

Dai, Feng ;

Barrett, Lee B. ;

Coppola, Giovanni ;

Wu, Tianxia ;

Kiselycznyk, Carly ;

Poddar, Minakshi ;

Lu, Yan ;

Diatchenko, Luda ;

Smith, Shad ;

Cobos, Enrique J. ;

Zaykin, Dmitri ;

Allchorne, Andrew ;

Shen, Pei-Hong ;

Nikolajsen, Lone ;

Karppinen, Jaro ;

Mannikko, Minna ;

Kelempisioti, Anthi ;

Goldman, David ;

Maixner, William ;

Geschwind, Daniel H. ;

max, Mitchell B. ;

Seltzer, Ze'ev ;

woolf, Clifford J. .

BRAIN, 2010, 133 :2519-2527

[10]

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans [J].

Dickendesher, Travis L. ;

Baldwin, Katherine T. ;

Mironova, Yevgeniya A. ;

Koriyama, Yoshiki ;

Raiker, Stephen J. ;

Askew, Kim L. ;

Wood, Andrew ;

Geoffroy, Cedric G. ;

Zheng, Binhai ;

Liepmann, Claire D. ;

Katagiri, Yasuhiro ;

Benowitz, Larry I. ;

Geller, Herbert M. ;

Giger, Roman J. .

NATURE NEUROSCIENCE, 2012, 15 (05) :703-712

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