Syntheses of the syn and anti alpha-amino-beta-hydroxy acids of vancomycin: (2S, 3R) and (2R, 3R) p-chloro-3-hydroxytyrosines.

被引：44

作者：

Girard, A ^{[1
]}

Greck, C ^{[1
]}

Ferroud, D ^{[1
]}

Genet, JP ^{[1
]}

机构：

[1] ROUSSEL UCLAF,CTR RECH,F-93235 ROMAINVILLE,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 44期

关键词：

D O I：

10.1016/0040-4039(96)01829-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of (2S, 3R) and (2R, 3R) methyl p-chloro-3-hydroxytyrosinates 2 and 3 respectively, have been achieved from 3-chloro-4-hydroxybenzoic acid. These approaches relied on the asymmetric hydrogenation of highly functionalized carbonyl derivatives using chiral ruthenium complexes. Copyright (C) 1996 Elsevier Science Ltd.

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页码：7967 / 7970

页数：4

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