A spontaneous nitric oxide donor ameliorates small bowel ischemia-reperfusion injury in dogs

被引：13

作者：

Kawata, K

Takeyoshi, I

Iwanami, K

Sunose, Y

Aiba, M

Ohwada, S

Matsumoto, K

Morishita, Y

机构：

[1] Gunma Univ, Sch Med, Dept Surg 2, Maebashi, Gumma 3718511, Japan

[2] Nippon Med Coll, Dept Pathol, Kawasaki, Kanagawa, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2001年 / 46卷 / 08期

基金：

美国国家卫生研究院;

关键词：

small intestine; ischemia-reperfusion injury; nitric oxide; FK409; intramucosal pH;

D O I：

10.1023/A:1010670008202

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nitric oxide (NO) appears to play an important role in tissue injury during reperfusion. FK409 is the first spontaneous NO donor that increases plasma guanosine 3 ' ,5 ' -cyclic monophosphate. We investigated the effects of the NO donor FK409 (FK) on ischemia-reperfusion injury in a canine warm ischemia model. Fourteen adult mongrel dogs were divided into two groups: the control group and the FK group, which received FK. The superior mesenteric artery and vein were both clamped for 2 h and then reperfused for 12 h. Arterial and intramucosal pH were well maintained in the FK group in comparison with the control group. Histologically, ischemia-reperfusion injury was significantly more severe in the control group than in the FK group. The serum NO levels were significantly higher in the FK group than in the control group during FK administration. FK409 has protective effects on ischemia-reperfusion injury of the small intestine due to NO release.

引用

页码：1748 / 1756

页数：9

共 46 条

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