Practical synthesis of enantiomerically pure 2-(diphenylphosphanyl)ferrocene carboxylic acid

被引：35

作者：

Breit, B ^{[1
]}

Breuninger, D ^{[1
]}

机构：

[1] Univ Freiburg, Inst Organ Chem & Biochem, D-79104 Freiburg, Germany

来源：

SYNTHESIS-STUTTGART | 2005年 / 16期

关键词：

metallocenes; asymmetric synthesis; synthetic methods; enantiomeric resolution; phosphorus;

D O I：

10.1055/s-2005-872111

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of both enantiomers of orthodiphenylphosphanylferrocene carboxylic acid (o-DPPFA) starting from ferrocene is described. Key steps include the synthesis of the racemic title compound from ferrocene in two steps followed by resolution by way of diastereomeric ester formation with glucose diacetonide. The synthesis allows for preparation of gram quantities of both optical antipodes of o-DPPFA (3) in good yields and enantiornerically pure form (> 99% ee).

引用

页码：2782 / 2786

页数：5

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