Estrogenic activity of phenolic compounds from Nigella damascena evaluated using a recombinant yeast screen

被引：18

作者：

Agradi, E

Fico, G

Cillo, F

Francisci, C

Tomè, F

机构：

[1] Univ Milan, Ist Sci Farmacol, Dipartimento Sci Farmacol, I-20133 Milan, Italy

[2] Univ Pisa, Dipartimento Chim Bioorgan & Biofarmacia, Pisa, Italy

[3] Univ Milan, Dipartimento Biol, Milan, Italy

来源：

PLANTA MEDICA | 2001年 / 67卷 / 06期

关键词：

D O I：

10.1055/s-2001-16485

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We used a yeast estrogen screen (YES) containing human estrogen receptor to evaluate the estrogenic activity of both crude extracts and simple pure phenolic compounds from Nigella damascena seeds. Estrogenic activity was established in the methanolic and aqueous extracts of the seeds as well as in two simple phenolic compounds isolated from the methanolic extract, 2,4-dihydroxyphenylacetic acid, 3,4-dihydroxy-beta -phenethyl alcohol.

引用

页码：553 / 555

页数：3

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