Heterogeneity of 5-HT receptors mediating secretion in the human intestine

被引：19

作者：

Borman, RA ^{[1
]}

Burleigh, DE ^{[1
]}

机构：

[1] UNIV LONDON QUEEN MARY & WESTFIELD COLL, DEPT PHARMACOL, LONDON E1 4NS, ENGLAND

来源：

RECEPTOR CLASSIFICATION: THE INTEGRATION OF OPERATIONAL, STRUCTURAL, AND TRANSDUCTIONAL INFORMATION | 1997年 / 812卷

关键词：

D O I：

10.1111/j.1749-6632.1997.tb48183.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In conclusion, application of 5-HT has been shown to induce fluid secretion in both the small and large intestine of man. By the use of selective antagonists, the receptors mediating these effects have been identified and characterized. 5-HT induces secretion across human ileal mucosa via a receptor of the 5-HT4 sub-type, whereas a receptor of the 5-HT(2A) sub-type appears to mediate the effect in human sigmoid colon. The response in human ascending colonic mucosa cannot be definitively classified at this time, but may reflect the presence of a heterogenous receptor population.

引用

页码：224 / 225

页数：2