In vitro activity of the ketolide ABT-773

被引：13

作者：

Barry, AL ^{[1
]}

Fuchs, PC ^{[1
]}

Brown, SD ^{[1
]}

机构：

[1] Inst Clin Microbiol, Wilsonville, OR 97070 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 10期

关键词：

D O I：

10.1128/AAC.45.10.2922-2924.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of ABT-773, azithromycin, erythromycin, and clindamycin were compared by testing 1,223 clinical isolates selected to represent different species and phenotypes. ABT-773 was particularly potent against staphylococci (the MIC at which 90% of the strains tested were inhibited [MIC90] was less than or equal to0.06 mug/ml), including all strains that were macrolide resistant but clindamycin susceptible. Streptococcus pneumoniae and other streptococci were inhibited by low concentrations of ABT-773, and that included most erythromycin-resistant strains. Against Haemophilus influenzae, ABT-773 and azithromycin were similar in their antibacterial potency (MIC90, 4.0 and 2.0 mug/ml, respectively).

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收藏

页码：2922 / 2924

页数：3

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