Plasmodium falciparum signal sequences:: simply sequences or special signals?

被引：26

作者：

Nacer, A

Berry, L

Slomianny, C

Mattei, D ^{[1
]}

机构：

[1] Inst Pasteur, Unite Biol Interact Hote Parasite, CNRS, URA 1960, F-75724 Paris, France

[2] Univ Lille 1, INSERM, EPI 9938, Lab Physiol Cellulaire, F-59655 Villeneuve Dascq, France

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 12期

关键词：

Plasmodium; protein trafficking; Brefeldin A; endoplasmic reticulum;

D O I：

10.1016/S0020-7519(01)00253-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The malaria parasite, Plasmodium falciparum, synthesises and exports several proteins inducing morphological and biochemical modifications of erythrocytes during the erythrocytic cycle. The protein trafficking machinery of the parasite is similar to that of other eukaryotic cells in several ways. However, some unusual features are also observed. The secretion of various polypeptides was inhibited when P. falciparum-infected erythrocytes were incubated with Brefeldin A. Immunoelectron microscopy studies revealed substantial morphological changes in the endoplasmic reticulum following exposure of parasitised erythrocytes to the drug. Immunofluorescence studies of Brefeldin A-treated parasites suggest that polypeptide sorting to different intracellular destinations begins at the endoplasmic reticulum. The parasite also secretes polypeptides by a Brefeldin A-insensitive route that bypasses the classical endoplasmic reticulum-Golgi complex pathway. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

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页码：1371 / 1379

页数：9

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